Due to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem. “Obesity and Lipotoxicity” is a comprehensive review of the recent researches to provide a better understanding of the lipotoxicity-related mechanisms of obesity and the potential for the development of new treatment strategies. This book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. Chapters examine the deleterious effects of nutrient excess at molecular level including the cellular and molecular aspects of breast cancer, resistance to leptin, insulin, adiponectin, and interconnection between the circadian clock and metabolic pathways during high-fat feeding. “Lipotoxicity and Obesity” will be a useful resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, cardiologists, as well as students who are thought in this field.

“The aim is to discuss the many critical and complex topics that trigger obesity with the hope that the book will encourage and further the research of scientists and practitioners who are interested in obesity. … This book is intended as a useful resource for clinicians and basic science researchers such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, and cardiologists, as well as students who are interested in this field.” (L. Anne Gilmore, Doody's Book Reviews, September, 2017)